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Health News
Newly found molecule disrupts cancer cells
PHILADELPHIA, Nov 5, 2009 (UPI via COMTEX) -- U.S. scientists say they have
discovered a small molecule that inhibits the actions of a protein cancer cells
require for survival.
The researchers said they determined the molecule, called PES, inhibits a type
of protein called a heat-shock protein that helps cells survive heat, lack of
nutrients and other cell-damaging conditions.
Assistant Professors Donna George and Julie Leu of the University of
Pennsylvania, along with Maureen Murphy of the Fox Chase Cancer Center, said
they found the molecule inhibits a heat shock protein that many cancer cells use
to repair damage and survive. PES disrupted the cancer cell's ability to rid
itself of damaged components and, as a result, PES halted tumor formation and
significantly extended the survival of mice.
Murphy said the molecule was equally effective in every type of cancer cell
tested.
That, she said, "is unusual and supports the idea that it is targeting a protein
that is required for the functioning of multiple pathways."
The scientists said they expect their findings to lead to development of
anti-cancer treatments.
The research appears in the journal Molecular Cell.
URL: www.upi.com
Copyright: Copyright 2009 by United Press International
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