Applied Nutriceuticals IGF-2

You’ve got to do a lot of things right to get the massive muscle size, density, strength and hardness you see among the nationally-ranked and pro-level bodybuilders. You’ve got to keep you protein intake high, train aggressively, manage your carb intake, get sufficient rest, etc. But let’s face it…you can do everything right and your gains will be still be limited unless you also do something to increase your testosterone and growth hormone levels. These two hormones are the most anabolic substances know to man – so it’s no wonder that serious bodybuilders administer them directly in various oral and injectable forms. Unfortunately these pharmaceutical-grade preparations are not readily available without a prescription, so for the rest of us, we must find another way.

Only IGF-2™ “Immediate Growth Factor” ™ provides the mechanisms to trigger exponential increases in both serum testosterone and human growth hormone levels! Better yet, the effects of this ground-breaking formulation can be felt just days after starting. Even hardcore bodybuilders with years of experience with steroids and growth hormone (HGH) rave about this formulation, reporting that it keeps them from “crashing” during off cycles, allowing for continuous, compound muscle growth! Every component of this revolutionary formula either directly or indirectly promotes testosterone and / or HGH production, while also triggering powerful fat-burning mechanisms. The result? Everything you want: Massive increases in muscle size, strength, leanness and density!

The synergistic compounds contained in IGF-2™ stimulate a variety of complex reactions and messenger systems in the body, and have been clinically proven to increase testosterone production. IGF-2 contains large amounts of Spirosta-steroidal saponins which are intermediates to numerous hormonal pathways in the body, including testosterone production. When ingested, desoxydiosgenin that is contained in IGF-2 is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is then converted to testosterone through the testes. Increased levels of testosterone signals the muscles to increase protein synthesis and nitrogen retention, leading to greater strength, size and recovery.

IGF-2 drives other dynamic biomechanisms including L-Dopa-induced growth hormone release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which ultimately hinders testosterone production. The variety of Mucuna Pruriens used in IGF-2 is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule. L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier. L-Dopa-induced GHRH release (growth hormone releasing hormone) signals the pituitary to release HGH. HGH is essentially a polypeptide hormone that stimulates skeletal muscle cells to grow and divide; providing for significant, permanent muscle hypertrophy in adults. HGH also aids in cellular recovery and acts synergistically with testosterone to provide a highly anabolic muscle-building environment.

IGF-2™ also stimulates the production of cyclic AMP (cAMP) from ATP. cAMP generation has a variety of effects on tissues, but the most notable is the stimulation of the thyroid to produce thyroxin, which promotes fat metabolization. The increased cAMP levels activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in target tissues. cAMP also signals for the production of luteinizing hormone (LH), which has been shown to elevate testosterone levels in males. Elevated levels of cAMP and LH stimulate a marked increase in the use of fat as body fuel, and are strongly correlated to increased testosterone production.

In a study conducted at the Tomsk State University and Medical Institute in Russia, the form of rhodiola rosea found in IGF-2 demonstrated the ability to stimulate greater ATP enhancement and creatine phosphate storage. Mice were administered rhodiola supplementation and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, and the rhodiola-treated mice were found to have 17% greater ATP levels, 45% greater creatine phosphate stores and 53% greater muscle glycogen levels. Decreased intramuscular concentrations of lactic acid and ammonia were also observed. In human studies, rhodiola has also been shown to have significant stress reduction effects by blocking cortisol release, which helps control muscle breakdown during training and/or stress.

In short; IGF-2 delivers the goods: Explosive growth. Accelerated recovery. Fat metabolization. Anti-catabolism. If you are serious about results, there really is no other choice.

486-0001
Applied Nutriceuticals
IGF-2
240 capsules

Nutrition Facts Serving Size: 1 Capsule (700mg) Servings Per Container: 240


		Amount Per Serving	% Daily Value*



	Chlorophytum Borivilanium (50% extract)

	Mucuna Pruriens (standardized to 75% L-Dopa)

	Rhodiola Rosea (1% rosavins)

	Dodder Seed Extract (20:1 cuscutta chineses)

	Bioprine (95-98% peperine)


*Percent Daily Values are based on a 2,000 calorie diet.


Other Ingredients: Maltodextrin M150, gelatin, titanium dioxide, FD&C blue #1.

Recommended Use: Take on an empty stomach first thing in the morning and the last dose at bedtime. SUGGESTED DOSAGE:Up to 150 lbs - 3 Capsules twice daily, 150-250 lbs - 4 Capsules twice daily, 250 lbs and over - 5 Capsules twice daily.

Warning: KEEP OUT OF REACH OF CHILDREN. This product is only intended to be consumed by healthy adults 18 years of age or older. Before using this product, seek advice from a physician if you are unaware of your current health condition or have any pre-existing medical condition including but not limited to: high or low blood pressurecardiac arrhythmia, stroke, heart, difficulty urinating due to prostate enlargement, psychiatric disease or bipolar disorder or if you are taking an MAO-B inhibitor or any other prescription or over the counter medication. Do not use if you are pregnant, nursing, prone to dehydration or exposed to excessive heat. Discontinue use and consult your health care professional if sleeplessness, tremors, dizziness, nervousness, headaches or heart palpitations occur or if you experience any adverse reaction to this product. Do not exceed recommended serving size. Before beginning any weight loss program consult your health care provider.

Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.


If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact Applied Nutriceuticals at 704-509-5999

A: Take first dose on an empty stomach first thing in the morning, 45 minutes before a meal. On non-workout days, take second dose in same fashion. On workout days, take second dose 45 minutes before workout, on an empty stomach. Take third dose on an empty stomach 45 minutes before bed time for maximum effectiveness.

Q: How long will it take me to notice the positive anabolic benefits from IGF-2?

A: You will begin to feel the testosterone and growth hormone increases from IGF-2 about 7-10 days after beginning the product, at which point you will notice measurable increases in strength and size. By the end of the third week, you’ll be feeling the full effects of this amazing product with ever-increasing gains in strength, size and density.

A: Not to be cynical, but this one actually works. We are proud that this product delivers exactly what we claim it to. The specifically titrated ratios of the compounds in IGF-2 trigger enormous increases in growth hormone and testosterone production, while serving a critical anti-catabolic function as well. Users of IGF-2 generally report lean body mass gains of 5-7 lbs. over an 8 week cycle, with even greater gains being reported when stacked with NeoVar, our advanced creatine product.

Q: How does IGF-2 boost testosterone levels, and how does testosterone grow more muscle?

A: The safed musli componet of IGF-2 contains large amounts of spirosta-steroidal saponins (desoxydiosgenin, tigogenin and neotigogenin) which are intermediates to various hormonal pathways in the body. When ingested, desoxydiosgenin from the safed musli is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is converted to testosterone through the testes. The testosterone produced binds to the androgen receptor, which signals the muscles via mRNA to increase protein synthesis, increased nitrogen retention and muscle cell hypertrophy; leading to greater strength, mass, and recovery.

Q: How does the L-Dopa in IGF-2 help with testosterone production and growth hormone secretion?

A: The variety of mucuna pruriens used in IGF-2™ is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule. Two important mechanisms of action of L-Dopa is increased growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can hinder testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. L-Dopa is a precursor to Dopamine, a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and somatostatin secretion in the hypothalamus, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, which is produced by the pituitary gland. GH is an important anabolic hormone that stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH also mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism.

A: Rhodiola rosea has been shown to increase ATP (Adenosine Triphosphate) production in the mitochondria of the cell. ATP is an energy molecule that allows for muscle contraction to occur. In a university study, mice were administered rhodiola and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the rhodiola-treated mice having 17% greater ATP levels, 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, along with lowered intramuscular concentrations of lactic acid and ammonia. What this means to you is stronger muscle contraction, allowing for improved energy and stamina.

In human studies, the rosavin and salidroside found in rhodiola rosea have also been shown to have significant effects on stress reduction. This is accomplished by reducing cortisol release, while optimizing levels of key brain chemicals involved in mood, such as serotonin and dopamine, which function together to maintain a healthy response to stress. Blocking cortisol is important, as cortisol tends to break down muscle tissue, increase body fat stores, slows the metabolism and lowers immune function. Rhodiola has been shown to have adaptogenic qualities, meaning that it allows humans to work harder during stress, while at the same time maintaining higher energy reserves.

A: Yes- we recommend that IGF-2 be taken in 8-10 week cycles to maximize effectiveness. The user should allow thirty days to pass before commencing a new cycle. Many use a two months on, one-month off philosophy with outstanding results.

A: Any serious athlete or bodybuilder looking to gain size and/or strength and speed recovery time. Endurance athletes can also benefit from IGF-2 as well; testing with IGF-2 was performed on Olympic-level track athletes who experienced measurable incremental improvements in speed plus reductions in muscle fatigue. Extensive testing has been also been conducted with nationally-ranked and IFBB pro bodybuilders and competitive power lifters, and the results in terms positive effects/benefits have been phenomenal. Additionally, all ingredients comply with IOC, NCAA, NFL, NBA, and MLB banned substances lists.